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Schatz, Booker Call For More Research On Therapeutic Potential Of Psychedelic Drugs U S. Senator Brian Schatz Although it is believed that dopaminergic systems are not directly involved in the mechanism of action of classic serotonergic hallucinogens, LSD is a unique agent with known high affinity and agonist activity at dopamine receptors (e.g., see Watts et al., 1995). Marona-Lewicka et al. first demonstrated that the effect of LSD as a training stimulus occurs in two temporal phases. When rats are trained to discriminate 0.08 mg/kg LSD, given 30 minutes prior to training , the stimulus generalizes to classic Psychedelics and is blocked by 5-HT2A receptor antagonists. If, however, LSD (0.16 mg/kg) is administered 90 minutes prior to training , the stimulus is no longer blocked by 5-HT2A antagonists, does not generalize to classic psychedelics, and is blocked by dopamine D2-like antagonists. In rats trained to discriminate LSD administered 90 minutes prior to training, the cue gene